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KMID : 1156220190450010018
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Journal of Environmental Health Sciences
2019 Volume.45 No. 1 p.18 ~ p.29
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Relationship between Risk Assessment Based on Urinary Bisphenol A Concentration and Allergic Diseases in Children
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Choi Ji-Hee
Hong So-Young
Kim Kyoo-Sang
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Abstract
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Objectives: The purpose of this study was to examine the relationship between urinary bisphenol A concentration and allergic diseases in children.
Methods: This study was conducted in Seoul, South Korea. We collected urine samples from 231 children from a single elementary school in June 2014. Among these, 69 children with urinary creatinine levels outside the normal range were excluded. Information on allergic diseases was obtained from the parents of the children. Urinary bisphenol A was analyzed using a liquid chromatography tandem mass spectrometer. Logistic regression analysis was used to determine if allergic disease was affected by urinary bisphenol A concentration.
Results: Girls had a significantly higher concentration of urinary bisphenol A than did boys (p<0.05). Children of 10-12 years old had a significantly higher concentration of urinary bisphenol A than did children 7-9 years old (p<0.01). Concentration of urinary bisphenol A was increased from underweight to overweight (p<0.05). As the concentration of urinary bisphenol A was increased by 1 μg/L or 1 μg/g creatinine, the risks of lifetime symptoms of atopic dermatitis in children was 1.22 times (95% CI; 1.05-1.41) or 1.08 times (95% CI; 1.01-1.15).
Conclusion: Concentration of urinary bisphenol A was associated with gender, age, body mass index, and allergic disease. Particularly, urinary bisphenol A concentration was associated with lifetime symptoms of atopic dermatitis. The findings of this study could contribute to the management of health effects among sensitive groups such as children.
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KEYWORD
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Allergic diseases, bisphenol A, children, risk assessment, urine
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